Biological Variation of Holo-Transcobalamin in Elderly
نویسندگان
چکیده
Individuals, Andrew McCaddon, Peter Hudson, Cherie McCracken, Richard Ellis, and Anne McCaddon ( University of Wales College of Medicine, Division of General Practice, Wrexham LL13 7YP, UK; 2 Department of Pathology, Wrexham Maelor Hospital, Wrexham LL13 7TD, UK; 3 University Department of Psychiatry, Royal Liverpool University Hospital, Liverpool L69 3GA, UK; 4 University Hospital of Wales, Cardiff CF14 4XW, UK; * address correspondence to this author at: Gardden Road Surgery, Rhosllanerchrugog, Wrexham, North Wales LL14 2EN, UK; fax 44-0-1978-845782, e-mail andrew@ mccaddon.demon.co.uk)
منابع مشابه
Zymographic analyses and measurement of matrix metalloproteinase-2 and -9 in nipple aspirate fluids.
related markers are early and responsive indicators of changes in vitamin B 12 status. Some indication of the size of what constitutes a significant change in serial holo-TC values is provided by the calculation of RCVs. The present study indicates that holo-TC values would need to change by nearly 50% for an investigator to be 95% certain that one value was significantly different from a previ...
متن کاملDirect assay for cobalamin bound to transcobalamin (holo-transcobalamin) in serum.
BACKGROUND Only cobalamin carried by transcobalamin (holo-transcobalamin) is available for cellular uptake and hence is physiologically relevant. However, no reliable or accurate methods for quantifying holo-transcobalamin are available. We report a novel holo-transcobalamin assay based on solid-phase capture of transcobalamin. METHODS A monoclonal antibody specific for human transcobalamin w...
متن کاملHolo-Transcobalamin Concentrations and Transcobalamin Saturation Reflect Recent Vitamin B12 Absorption Better than Does Serum Vitamin B12
Background: We evaluated whether measurement of vitamin B12-saturated transcobalamin (holo-TC) concentrations or TC saturation (holo-TC:total TC) reflects active vitamin B12 absorption in healthy individuals and patients after vitamin B12 intake. Methods: We obtained blood samples from 31 healthy individuals (age range, 25–57 years) before (days 1 and 0) and after (days 1, 2, and 6) oral admini...
متن کاملHolo-transcobalamin is an early marker of changes in cobalamin homeostasis. A randomized placebo-controlled study.
BACKGROUND We examined the effect of oral vitamin B(12) treatment on fluctuations in plasma total cobalamin and its binding proteins transcobalamin (TC) and haptocorrin (HC). METHODS Patients (n = 88; age range, 38-80 years) undergoing coronary angiography (part of the homocysteine-lowering Western Norway B-Vitamin Intervention Trial) were allocated to daily oral treatment with (a) vitamin B(...
متن کاملFirst trimester serum levels of the soluble transcobalamin receptor, holo-transcobalamin, and total transcobalamin in relation to preeclampsia risk.
BACKGROUND Human placenta expresses CD320, a receptor that ensures the uptake of holo-transcobalamin (holoTC). Soluble CD320 (sCD320) is present in the circulation and its concentration increases during pregnancy. AIMS To investigate a possible association of sCD320, holoTC and total transcobalamin (TC) with the risk of subsequent preeclampsia using serum samples from asymptomatic first trime...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2003